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Wakefulness

Effects upon the brain: – Longer wakefulness increases synchronous firing rates of cerebral cortex neurons – Neuronal firing speed and synchronicity decrease after sustained sleep […]

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Effects upon the brain:
– Longer wakefulness increases synchronous firing rates of cerebral cortex neurons
– Neuronal firing speed and synchronicity decrease after sustained sleep
– Wakefulness reduces glycogen in astrocytes, which supply energy to neurons
– Sleep replenishes glycogen energy source in the brain
– Brain activity changes with wakefulness and sleep cycles

Maintenance by the brain:
– Wakefulness is regulated by neurotransmitter systems in the brainstem
– Posterior hypothalamus is key for maintaining cortical activation during wakefulness
– Histamine neurons and orexins play essential roles in controlling wakefulness
– Orexin deficiency can lead to narcolepsy
– Orexin and histamine neurons have distinct roles in controlling wakefulness

See also:
– Dream argument
– Eugeroic
– High-conductance state
– Lucid dream
– Sleepwalking

References:
– Sleep, dreams and wakefulness
– Wakefulness, Alertness, Sleep, and Dreams
– The Consequences of Excessive Wakefulness
– Cortical firing and sleep homeostasis
– Control of Sleep and Wakefulness

Wakefulness (Wikipedia)

Wakefulness is a daily recurring brain state and state of consciousness in which an individual is conscious and engages in coherent cognitive and behavioral responses to the external world.

Being awake is the opposite of being asleep, in which most external inputs to the brain are excluded from neural processing.

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