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Circadian rhythm sleep disorder

Overview of Circadian Rhythm Sleep Disorders: – Circadian rhythms control biological activities over roughly a 24-hour period. – Disruptions in circadian processes can lead to […]

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Overview of Circadian Rhythm Sleep Disorders:
– Circadian rhythms control biological activities over roughly a 24-hour period.
– Disruptions in circadian processes can lead to circadian rhythm sleep disorders (CRSDs).
– Sleep-wake cycles are regulated by circadian processes.
– CRSDs can cause disturbances in sleep timing.
– The suprachiasmatic nucleus (SCN) regulates circadian rhythms in humans.
– Genes like BMAL1 and CLOCK regulate light-induced entrainment.
– Around 3% of adults are estimated to have a CRSD.
– Misdiagnosis with insomnia is common.
– Adolescents with sleep disorders may have a CRSD (16%).
– Diagnosis involves gathering sleep history, body temperature patterns, and DLMO.

Impact and Treatment of Circadian Rhythm Sleep Disorders:
– CRSD can lead to impaired daily functioning.
– It can affect work performance, social interactions, and mental health.
– Relationship problems and reduced quality of life are common outcomes.
– Light therapy, behavioral therapy, and melatonin supplements are common treatments.
– Chronotherapy involves gradually shifting sleep schedules.
– Medications like stimulants or sedatives may be used in severe cases.

Intrinsic Circadian Rhythm Sleep Disorders:
– Delayed Sleep Phase Disorder (DSPD) leads to delayed sleep-wake times.
– Advanced Sleep Phase Disorder (ASPD) shows advanced sleep-wake times.
– Familial Advanced Sleep Phase Syndrome (FASPS) is linked to a genetic mutation.
– Irregular Sleep-Wake Rhythm Disorder (ISWRD) involves fragmented sleep patterns.
– Non-24-hour Sleep-Wake Disorder (N24SWD) is common in blind individuals.

Extrinsic Circadian Rhythm Sleep Disorders:
– Shift Work Sleep Disorder (SWSD) affects about 9% of Americans working irregular shifts.
– Jet lag results from misalignment between internal circadian system and external cues.
– Alzheimer’s disease patients commonly experience circadian rhythm sleep disorders.
– Melatonin alteration and circadian rhythm irregularity in Alzheimer’s patients can worsen cognitive abilities.
– Sleep-wake disturbances impact AD patients’ cognitive abilities, emotional state, and quality of life.

Genetic Basis and Treatment of Circadian Rhythm Disorders:
– Genetic studies explore the basis of human circadian rhythm disorders.
– Chronotherapy and light therapy are effective treatments for circadian rhythm disorders.
– Melatonin administration and dark therapy can aid in treating CRSDs.
– Various research studies and resources provide insights into circadian rhythm disorders and their management.

Circadian rhythm sleep disorder (Wikipedia)

Circadian rhythm sleep disorders (CRSD), also known as circadian rhythm sleep-wake disorders (CRSWD), are a family of sleep disorders which affect the timing of sleep. CRSDs arise from a persistent pattern of sleep/wake disturbances that can be caused either by dysfunction in one's biological clock system, or by misalignment between one's endogenous oscillator and externally imposed cues. As a result of this mismatch, those affected by circadian rhythm sleep disorders have a tendency to fall asleep at unconventional time points in the day. These occurrences often lead to recurring instances of disturbed rest, where individuals affected by the disorder are unable to go to sleep and awaken at "normal" times for work, school, and other social obligations. Delayed sleep phase disorder, advanced sleep phase disorder, non-24-hour sleep–wake disorder and irregular sleep–wake rhythm disorder represents the four main types of CRSD.

Circadian rhythm sleep disorder
Other namesCircadian rhythm sleep-wake disorders
SpecialtyPsychiatry, neurology, chronobiology
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