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VRK2

– References: – GRCh38: Ensembl release 89: ENSG00000028116Ensembl, May 2017 – GRCm38: Ensembl release 89: ENSMUSG00000064090Ensembl, May 2017 – Human PubMed Reference: National Center for […]

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– References:
– GRCh38: Ensembl release 89: ENSG00000028116Ensembl, May 2017
– GRCm38: Ensembl release 89: ENSMUSG00000064090Ensembl, May 2017
– Human PubMed Reference: National Center for Biotechnology Information, U.S. National Library of Medicine
– Mouse PubMed Reference: National Center for Biotechnology Information, U.S. National Library of Medicine
– Entrez Gene: VRK2 vaccinia related kinase 2

– Further reading:
– Blanco S, Santos C, Lazo PA (2008). Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1
– Li LY, Liu MY, Shih HM, et al. (2006). Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival
– Blanco S, Klimcakova L, Vega FM, Lazo PA (2006). The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines
– Gerhard DS, Wagner L, Feingold EA, et al. (2004). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
– Nichols RJ, Traktman P (2004). Characterization of three paralogous members of the Mammalian vaccinia related kinase family

– Kinases:
– Serine/threonine-specific protein kinases (EC 2.7.11-12)
– Non-specific serine/threonine protein kinases (EC 2.7.11.1)
– Pyruvate dehydrogenase kinase (EC 2.7.11.2)
– Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
– 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)

– Protein kinases:
– cAMP-dependent protein kinase (EC 2.7.11.11)
– cGMP-dependent protein kinase (EC 2.7.11.12)
– Protein kinase C (EC 2.7.11.13)
– IκB kinase (EC 2.7.11.10)
– Aurora kinase (Aurora A kinase, Aurora B kinase, Aurora C kinase)

– Receptor protein serine/threonine kinases:
– Bone morphogenetic protein receptors (BMPR1, BMPR1A, BMPR1B, BMPR2, ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Müllerian hormone receptor)
– Receptor protein serine/threonine kinase (EC 2.7.11.30)
– G-protein coupled receptor kinases (GRK4, GRK5, GRK6)
– Beta adrenergic receptor kinases (Beta adrenergic receptor kinase, Beta adrenergic receptor kinase-2)
– Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)

VRK2 (Wikipedia)

Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the VRK2 gene.

VRK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVRK2, vaccinia related kinase 2, VRK serine/threonine kinase 2
External IDsOMIM: 602169 MGI: 1917172 HomoloGene: 55966 GeneCards: VRK2
EC number2.7.11.1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252447
NM_027260

RefSeq (protein)

NP_001239376
NP_081536

Location (UCSC)Chr 2: 57.91 – 58.16 MbChr 11: 26.42 – 26.54 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation.

While several transcript variants may exist for this gene, the full-length nature of only one has been biologically validated to date.

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