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Neurovirology

Neurovirology Overview and History: – Neurovirology is a field that emerged in the past 30 years, focusing on virus-induced diseases of the nervous system. – […]

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Neurovirology Overview and History:
– Neurovirology is a field that emerged in the past 30 years, focusing on virus-induced diseases of the nervous system.
– It integrates virology, neuroscience, neurology, immunology, and molecular biology.
– The field traces its origins back to rabies research in the late 1880s and has seen pioneering discoveries by notable figures.
– The research foundation was established in the late 1980s and 1990s, with recognition from the International Society of Neurovirology.

Viral Entry Mechanisms and Diagnostic Tools in Neurovirology:
– Viruses utilize transneuronal spread and hematogenous spread to infiltrate the nervous system.
– Diagnostic tools in neurovirology include neuroimaging (CT, MRI), CSF analysis, PCR, serology, and brain biopsy for histological evidence.

Research and Therapy in Neurovirology:
– Antiviral treatments have limitations in diseases like Multiple Sclerosis and AIDS dementia.
– Potential use of HSV-1 for gene therapy in neurological diseases.
– Constant expansion and development of new technology and therapies are vital for addressing emerging viral infections and advancing the field.

Related Fields:
– Neuroimmunology: Study of interactions between the nervous system and immune system, focusing on immune responses in neurological diseases.
– Neurology: Branch of medicine dealing with disorders of the nervous system, involving diagnosis and treatment of various conditions.
– Virology: Study of viruses and viral diseases, including viral structure, replication, and mechanisms of infection.

Clinical Neurovirology:
– Clinical neurovirology involves the study of viral infections affecting the nervous system, with a focus on diagnosis, treatment, and prevention of viral neurologic diseases.
– Research includes diseases like herpes simplex virus encephalitis and HIV-associated neurocognitive disorders, emphasizing viral pathogenesis and immune responses. Clinical neurovirologists collaborate with infectious disease specialists and neurologists.

Neurovirology (Wikipedia)

Neurovirology is an interdisciplinary field which represents a melding of clinical neuroscience, virology, immunology, and molecular biology. The main focus of the field is to study viruses capable of infecting the nervous system. In addition to this, the field studies the use of viruses to trace neuroanatomical pathways, for gene therapy, and to eliminate detrimental populations of neural cells.

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