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Neuropeptide S receptor

Clinical Significance of Neuropeptide S Receptor: – NPS activation in the CNS promotes arousal and anxiolytic effects. – Mutations in NPSR are linked to asthma […]

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Clinical Significance of Neuropeptide S Receptor:
– NPS activation in the CNS promotes arousal and anxiolytic effects.
– Mutations in NPSR are linked to asthma susceptibility, such as rs3249801 (A107I).
– NPSR activation in the airway epithelium upregulates matrix metalloproteinases associated with asthma pathogenesis.
– NPSR activation affects gastrointestinal motility and mucosal permeability simultaneously.

Genetic Associations and Study Findings:
– GPRA (G protein-coupled receptor for asthma susceptibility) is linked to asthma traits.
– NPSR1 mutations like Y206H are found in individuals needing less sleep.
– Studies show associations between gene polymorphisms and asthma-related traits.
– Structure-function relationships in NPSR1 due to asthma-associated mutations are studied.

Gastrointestinal Effects of Neuropeptide S Receptor:
– Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide.
– Activation of NPSR affects gastrointestinal functional and inflammatory reactions.
– Aberrant NPSR1 signaling could worsen gastrointestinal dysmotility and hyperpermeability.
– Implications of NPSR in gastrointestinal health and inflammatory responses are explored.

Research Focus and Publication Details:
– Research focuses on genetic factors and asthma susceptibility, gene polymorphisms, and molecular consequences of mutations.
– Lung expression and function of NPSR1/GPRA in asthma-like diseases are studied.
– Identification of downstream target genes in the neuropeptide S-NPSR1 pathway.
– Studies are published in journals like the Journal of Investigative Dermatology and Human Molecular Genetics.

Authors, Collaborators, and Further Reading:
– Various authors and collaborators contribute to research on neuropeptide S receptor.
– Further reading includes studies on asthma genetics, signaling properties of related receptors, and GPCR polymorphisms linked to asthma.
– References to key studies and research on neuropeptide S effects are highlighted.

Neuropeptide S receptor (Wikipedia)

The neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Mutations in this gene have also been associated with this disease.

AliasesNPSR1, ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1, neuropeptide S receptor 1
External IDsOMIM: 608595 MGI: 2441738 HomoloGene: 45515 GeneCards: NPSR1
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 34.66 – 34.88 MbChr 9: 24.01 – 24.23 Mb
PubMed search
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