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Imaging genetics

– Imaging Genetics: – Anatomical or physiological imaging technologies used as phenotypic assays for genetic variation. – Functional neuroimaging investigates genes expressed in the brain […]

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– Imaging Genetics:
– Anatomical or physiological imaging technologies used as phenotypic assays for genetic variation.
– Functional neuroimaging investigates genes expressed in the brain (neuroimaging genetics).
– Research combines genetic information and fMRI data to define neuro-mechanisms linked to genetic variation.
– Individual differences in single nucleotide polymorphisms (SNPs) lead to variations in brain wiring structure and intellectual function.
– Direct observation of the link between genes and brain activity to understand common diseases.

– Alzheimer’s Disease:
– Genetic information enhances prediction of Alzheimer’s disease (AD) when combined with neuro-imaging data.
– APOE4 allele is a confirmed genetic risk factor for late-onset AD.
– CLU gene risk variant affects white matter integrity, increasing vulnerability to AD.
– CLU-C allele associated with lower FA in various brain regions.
– Structural brain mapping in those at genetic risk of AD is crucial for treatment and prevention strategies.

– Biomarkers and Alzheimer’s Spectrum:
– Suitable biomarkers can aid in diagnosing the AD spectrum at earlier stages.
– AD spectrum divided into preclinical, mild cognitive impairment, and clinical AD stages.
– Biomarkers help in understanding the transition from preclinical to AD stages.
– Early detection via biomarkers can lead to interventions for AD prevention.
– Biomarkers can be utilized to define each stage of the AD spectrum clearly.

– Future:
– Imaging genetics needs methods to relate effects of numerous genetic variants on multi-dimensional neuroimaging phenotypes.
– Emerging field of imaging epigenetics is relevant for understanding trauma-related psychopathology and maternal care disturbances.

– Problems:
– Medication, hospitalization history, or associated behaviors like smoking can impact imaging results.

Imaging genetics (Wikipedia)

Imaging genetics refers to the use of anatomical or physiological imaging technologies as phenotypic assays to evaluate genetic variation. Scientists that first used the term imaging genetics were interested in how genes influence psychopathology and used functional neuroimaging to investigate genes that are expressed in the brain (neuroimaging genetics).

Imaging genetics uses research approaches in which genetic information and fMRI data in the same subjects are combined to define neuro-mechanisms linked to genetic variation. With the images and genetic information, it can be determined how individual differences in single nucleotide polymorphisms, or SNPs, lead to differences in brain wiring structure, and intellectual function. Imaging genetics allows the direct observation of the link between genes and brain activity in which the overall idea is that common variants in SNPs lead to common diseases. A neuroimaging phenotype is attractive because it is closer to the biology of genetic function than illnesses or cognitive phenotypes.

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