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Advanced sleep phase disorder

Advanced Sleep Phase Disorder (ASPD) Overview: – Symptoms include: – Inability to stay awake until conventional bedtime – Falling asleep too early in the evening […]

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Advanced Sleep Phase Disorder (ASPD) Overview:
– Symptoms include:
– Inability to stay awake until conventional bedtime
– Falling asleep too early in the evening
– Early morning insomnia
– Altered melatonin levels and core body temperature cycle
– Diagnosis methods:
– Sleep studies like polysomnography
– Measurement of sleep onset and offset, dim light melatonin onset
– Consideration of age and family history
– Epidemiology:
– More common in middle and older adults
– Estimated prevalence around 1% in middle-age adults
– Equal prevalence in men and women
– Familial Advanced Sleep Phase Syndrome (FASPS):
– Individuals wake up much earlier than average population
– Treatment involves sleep scheduling and bright light therapy

Genetic Basis and Mechanisms of ASPD:
– FASPS locus mapped to chromosome 2q
– Per2 gene identified as crucial for circadian rhythms
– CK1 binding to PER2 regulates protein levels
– Mutations in CKIδ and PER2 binding domain cause circadian disruptions
– Genetic studies on human Per2 S662G mutation and circadian period

Circadian Mutation Studies and Insights:
– Menaker and Ralph discovered a mutation in golden hamsters’ circadian system
– Xu et al. explored human circadian mutations and CKIδ mutation
– Insights gained contribute to understanding circadian rhythm regulation
– Key publications in Science, Cell, and Nature journals
– Researchers like Xu, Toh, Jones, and Ptáček instrumental in circadian mutation studies

Treatment and Management of ASPD:
– Bright light therapy and chronotherapy used for treatment
– Pharmacological approaches less successful
– Social obligations may disrupt circadian rhythm
– Chronic sleep deprivation and other disorders may result from delayed sleep
– Studies on therapeutic approaches for circadian rhythm sleep disorders

Classification, Genetic Insights, and Scientific Impact:
– ASPD classified under ICD-11 as 7A61
– Genetic mutations in PER2 and CKIδ lead to ASPD
– Understanding genetic factors crucial for diagnosis and treatment
– Scientific advancements in circadian mutation studies impact personalized medicine
– Continued exploration of genetic and molecular aspects of circadian rhythms for improved healthcare outcomes

Advanced sleep phase disorder (Wikipedia)

Advanced Sleep Phase Disorder (ASPD), also known as the advanced sleep-phase type (ASPT) of circadian rhythm sleep disorder, is a condition that is characterized by a recurrent pattern of early evening (e.g. 7-9 PM) sleepiness and very early morning awakening (e.g. 2-4 AM). This sleep phase advancement can interfere with daily social and work schedules, and results in shortened sleep duration and excessive daytime sleepiness. The timing of sleep and melatonin levels are regulated by the body's central circadian clock, which is located in the suprachiasmatic nucleus in the hypothalamus.

Advanced Sleep Phase Disorder
SpecialtyChronobiology
SymptomsEarlier than desired onset and offset of sleep
ComplicationsSleep deprivation
Risk factorsIncreased incidence with age
Diagnostic methodPolysomnography, Horne-Ostberg morningness-eveningness questionnaire
TreatmentBright light therapy, chronotherapy
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